T-cells

December 18, 2017December 19, 2017

Cell Recycling Process Helps Trigger Immune Attack on Protective Nerve Cell Protein Myelin

News

A cell recycling process helps trigger an immune response against myelin, the protective layer covering nerve cell axons to aid in signal transmission, a multiple sclerosis ... Read more

November 22, 2017November 22, 2017

Gut Bacteria Contribute to MS Onset and Development, Rutgers Mouse Study Shows

News

Exposure to certain gut bacteria at a young age may cause multiple sclerosis (MS) and fuel its progression, a new mouse study shows. The study, “Gut ... Read more

November 6, 2017November 5, 2017

MS News That Caught My Eye Last Week: Older Patients, Stem Cells, Myelin, B-cells vs. T-cells

Columns, The MS Wire - A Column by Ed Tobias

#MSParis2017 – Trial to See if Disease-modifying Therapies Not Necessary in Older MS Patients This tops my list this week because, at age 69, I certainly ... Read more

November 2, 2017

MS Martial Arts: Battle B-neath the Surface

Multiple sclerosis is a progressive neurological disease that develops when the myelin in the central nervous system is attacked, leading to a range of symptoms including mobility ... Read more

October 31, 2017October 31, 2017

#MSParis2017 – T-cell vs. B-cell Debate More Meeting of Minds Than ‘Rumble in the Jungle’

News

News commentary One particular session on Day 2 of the four-day 7th Joint ECTRIMS-ACTRIMS Meeting — which drew 10,000 researchers, doctors, industry representatives, and patient advocates ... Read more

October 25, 2017October 26, 2017

#MSParis2017 – Researchers Suggest Propionic Acid Could Be Used as Add-on Treatment in MS

News

Propionic acid supplements alter the composition and behavior of immune cells in multiple sclerosis (MS) patients — likely by changing the composition of gut bacteria, according ... Read more

October 24, 2017October 26, 2017

Atara Biotherapeutics Starts Phase 1 Clinical Trial of Its MS Immunotherapy ATA188

News

Atara Biotherapeutics has started a Phase 1 clinical trial to assess ATA188’s safety and potential to treat progressive or relapsing-remitting multiple sclerosis. ATA188 is the company’s next-generation T-cell immunotherapy. ... Read more

October 19, 2017October 20, 2017

Inhibiting HDAC1 Enzyme Prevents Mice from Developing MS-like Disease, Study Finds

News

Inhibiting an enzyme prevented mice from developing a multiple sclerosis-like disease, a European study reports. The finding about HDAC1, a member of the histone deacetylases family of enzymes, could ... Read more

September 14, 2017September 13, 2017

The MS Alphabet: Hemiparesis, Helper T-cells, HLA and Other ‘H’ Terms

Columns, MS in Moderation, a column by Tamara Sellman

(Editor’s note: Tamara Sellman continues her occasional series on the MS alphabet with this column about terms starting with the letter H.) Symptoms of MS Hemiparesis ... Read more

August 23, 2017August 24, 2017

Researchers Identify Nerve Pathway Linking Brain Inflammation, Gut Dysfunction in MS

News

Chronic stress and inflammation in the brain can cause multi-organ dysfunction including severe gut failure, mediated by a newly identified nerve pathway in animal models of ... Read more

August 16, 2017August 16, 2017

Enzyme Regulates Development of Specific T-cells That Contribute to Autoimmune Disease, Study Suggests

News

A new study highlights a crucial role for the enzyme protein tyrosine phosphatase N2 in the development of early immune T-cells, and suggests that decreased levels ... Read more

July 7, 2017July 11, 2017

Mavenclad Reduces MS Relapses by Reseting the Immune System

News

New analyses of how Merck’s Mavenclad (cladribine tablets) act to treat relapsing multiple sclerosis (MS) give researchers an entirely new picture of immune processes leading to ... Read more

June 14, 2017June 14, 2017

Stressful Environment Triggers Inflammatory Cells Linked to Autoimmune Diseases Like MS, Study Shows

News

A stressful microenvironment, characterized by low metabolites and low oxygen levels, triggers the generation of immune cells directly implicated in a variety of inflammatory diseases, such ... Read more

June 13, 2017June 13, 2017

Unpublished Data May Point to Link Between Lemtrada and Other Autoimmune Diseases in MS Patients

News

Previously unpublished results of clinical trials of Lemtrada (alemtuzumab) appears to contain key information as to why many multiple sclerosis patients who use it develop other autoimmune ... Read more

June 7, 2017June 7, 2017

Ocrevus Phase 3 Trial Will Explore How Treatment Works by Viewing Changes in Spinal Fluid

News

Already an approved treatment for relapsing and primary progressive multiple sclerosis (MS), Ocrevus (ocrelizumab) is still undergoing scrutiny in several clinical trials. Most focus on the drug’s effects ... Read more

May 23, 2017May 23, 2017

Brain IFN-gamma Drives MS Disease Processes, Russian Immune Factor Analysis Finds

News

MS brain inflammation is a result of interactions between processes in the brain and the rest of the body, with interferon-gamma (IFN-gamma) being a key player, ... Read more

May 4, 2017May 4, 2017

Cytomegalovirus Infection Worsens Multiple Sclerosis, Study in Mice Shows

News

A cytomegalovirus infection triggers an increase in inflammatory and cytotoxic immune cells in mice with multiple sclerosis (MS), which leads to enhanced inflammation and loss of nerve-protecting ... Read more

April 7, 2017April 7, 2017

Exposure to Antibiotics Early in Life May Increase Risk for MS and Other Inflammatory Diseases, Study Suggests

News

The use of antibiotics in childhood, which alters the microbiome — or natural bacteria flora in the gut — may increase the risk of multiple sclerosis (MS), ... Read more

April 6, 2017

What Role Do B-Cells Play in Multiple Sclerosis?

In this video from Rachelle Ramirez, find out more about the important role the body’s B-cells play in the development of multiple sclerosis. MORE: A study has found ... Read more

April 5, 2017April 5, 2017

UCSF Neurologist Played Key Role in MS Research Turning to B-Cells, Essential Step to Ocrevus

News

Dr. Stephen Hauser, chair of the neurology department at the University of California San Francisco, was instrumental in the early research and later clinical trials that ultimately ... Read more

April 5, 2017April 5, 2017

UMD Team Reverses Paralysis in MS Mouse Model Using Novel Immunotherapy Strategy

News

Scientists at the University of Maryland have developed an experimental treatment to control the immune system and recover movement in a paralyzed mouse model of multiple sclerosis ... Read more

March 20, 2017March 20, 2017

EBI2 Receptor Facilitates T-cell Invasion of Brain in MS, Animal Study Shows

News

Scientists have identified a receptor that promotes the influx of damaging immune T-cells into the brain of a mouse model of human multiple sclerosis (MS). The ... Read more

March 6, 2017March 6, 2017

Altered Immune Response in MS Is What May Allow Infections to Kill, Mouse Study Suggests

News

It is no coincidence that multiple sclerosis (MS) patients are prone to airway infections, according to research showing that MS disease processes allow suppressive immune cells ... Read more

February 24, 2017February 24, 2017

#ACTRIMS2017 – Some Fatty Acids in Diet Help, Others Hurt Immune System, Study Reports

News

Short-chain dietary fatty acids, such as propionate, drive the production of regulatory immune T-cells in patients with multiple sclerosis (MS), while long-chain acids promote T-cells that ... Read more

February 23, 2017February 23, 2017

#ACTRIMS2017 – Airway Infections May Be More Common in MS Due to Altered Immune Response in Lungs

News

Disease processes in multiple sclerosis (MS) likely contribute to the increased sensitivity to airway infections seen in MS patients, a series of experiments in mice demonstrated. The ... Read more

January 10, 2017January 10, 2017

Researchers Identify 2 Cytokines Responsible for Chronic Flares in Autoimmune Diseases

News

Researchers have identified two factors that allow Th17 cells —  which drive multiple sclerosis (MS) and other autoimmune conditions — to form memory cells in the body and ... Read more

December 6, 2016December 6, 2016

Study Detailing New Way T-cells Attack Myelin May Explain Why Some MS Therapies Fail

News

In a new and possibly important insight into the workings of the immune system, researchers discovered what it takes for T-cells to start targeting myelin sheets ... Read more

November 23, 2016November 23, 2016

New Research into T-cells May Lead to Immune-based Therapies for MS, Other Diseases

News

A recent study published in Nature Communications showed, for the first time, that a protein complex called LUBAC is responsible for controlling the late-stage development of immune ... Read more

October 28, 2016October 28, 2016

Relapses in MS Patients Using Gilenya May Be Result of Changes Within T-Cells, Study Reports

News

Changes in the composition of certain immune system cells may be associated with relapses in multiple sclerosis (MS) patients being treated with Gilenya (fingolimod), according to a ... Read more

October 21, 2016October 31, 2016

Umbilical Cord Stem Cells Work to Restore Immune System Balance in Early Study

News

Damaging immune system defects seen in patients with multiple sclerosis (MS) can be repaired using a simple stem cell approach, according to a new study by researchers in ... Read more

October 17, 2016

MS Martial Arts: Battle B-neath the Surface

Multiple sclerosis is a progressive neurological disease that develops when the myelin in the central nervous system is attacked, leading to a range of symptoms including mobility ... Read more

October 12, 2016October 12, 2016

Potential Therapy, Laquinimod, Shows Promise as Progressive MS Treatment in Mouse Study

News

The experimental therapy laquinimod was seen to prevent the start of harmful immune responses and to disrupt the progression of multiple sclerosis (MS) in a mouse model of ... Read more

September 27, 2016September 27, 2016

Future MS Treatment: Selectively Targeting T-cells May Come As Temporary Tattoo

News

Antioxidant-filled nanoparticles injected under the skin may become a future multiple sclerosis (MS) treatment that comes with a perk or a drawback, depending on how a ... Read more

September 27, 2016September 27, 2016

How Tecfidera Works to Reduce MS Relapses Finally Discovered, May Lead to Better Treatments

News

How the multiple sclerosis (MS) therapy Tecfidera (dimethyl fumarate) works on a molecular level has finally been uncovered, using a new method that can map a drug’s protein targets. The insights ... Read more

September 14, 2016September 14, 2016

#ECTRIMS2016 – Benefits of Gilenya in MS Also Appear Linked to Its Effects on B-Cells

News

Scientists recently reported additional mechanisms of action that may underlie Gilenya (fingolimod) beneficial effects in relapsing-remitting multiple sclerosis (RRMS). The results were in an oral presentation, “Fingolimod ... Read more

May 24, 2016May 24, 2016

JC Virus Carries a Mutation in MS Patients That Amplifies Brain Disease Known as PML

News

A mutation in a mouse model of the John Cunningham (JC) virus, which causes progressive multifocal leukoencephalopathy (PML), allows the virus to evade the host immune responses in ... Read more

May 3, 2016May 3, 2016

Opexa’s CEO Gives Update on T-Cell Therapy at Vatican Conference

News

Opexa Therapeutics, Inc., announced that its president and chief executive officer, Neil K. Warma, recently gave a presentation on immunotherapy and its potential for treating autoimmune disorders, including multiple sclerosis, ... Read more

March 21, 2016March 21, 2016

CONy16: Pros and Cons of MS Drugs Targeting Immune Cells Other Than B-cells Debated

News

Clinical trials have shown that ocrelizumab — an antibody targeting B-cells — is effective in multiple sclerosis (MS). As a result, some researchers and clinicians claim that ... Read more

March 21, 2016March 22, 2016

CONy16: Sanofi Genzyme Symposium on MS Therapies Targeting T and B Cells; Exclusive Interview with Lead Researcher

News

Sanofi Genzyme, one of the companies participating in the four-day 10th World Congress on Controversies in Neurology (CONy) in Lisbon, Portugal, that concluded on March 20, 2016, supported several symposiums ... Read more

February 24, 2016February 24, 2016

MS Society Funds Research Using Zebrafish to Observe CD46 Protein and Its Role in Brain Inflammation

News

In an innovative research project funded by the National Multiple Sclerosis Society, Dr. Anne Astier from the University of Edinburgh, U.K., and her team will use ... Read more