Living With MS: Switching Medications

In this video, Lauren Parrot vlogs about multiple sclerosis and her fears about switching her medication from Tysabri to Ocrelizumab.

First potential therapy for primary progressive MS, Ocrelizumab, under priority review by the FDA. Read more.

Lauren’s been taking Tysabri for almost nine years and has been advised to switch to Ocrelizumab because she is JCV positive (John Cunningham’s virus) and at risk of contracting progressive multifocal leukoencephalopathy (PML)–a rare brain disease. Lauren is uncertain of her future with the new treatment and understandably scared about transitioning from one medication to another.

New guidelines for MS patients taking Tysabri for controlling rare brain infection risk. Read more.

Multiple Sclerosis News Today is strictly a news and information website about the disease. It does not provide medical advice, diagnosis or treatment. This content is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or another qualified health provider with any questions you may have regarding a medical condition. Never disregard professional medical advice or delay in seeking it because of something you have read on this website.


  1. Ken Boate says:

    Hi Lauren,
    Thank you for opening up your feelings about dealing with both the connection with your Neurologist & Medication.
    I too was on Tysabri for about two years and had to switch meds. Then went to Copaxone for a few years, and had to go to another medication, which is now Techfidera. I too loved Tysabri. But like you, we continue to move forward. You seem to be doing very well, and wanted to thank you for the Honest Feelings shown. Stay Positive and keep moving!!

  2. Joanne says:

    Hi Lauren,
    I have been on Tysabri for 3.5 years. I tested positive for the first time when results came back from my blood test in September. I jumped from zero to 3 point something. I saw my MS specialist last week and we have also made the decision to switch me to Ocrelizumab/Rituxan. I’m a little apprehensive but if the switch goes well it means I’ll only be getting an infusion every six months (after the initial two infusions). I try not to worry about the “ifs”. There are many other choices out there for treating MS. This has been my third medication and I’m thankful that there have been no new lesions on my MRI’s since I began. I was diagnosed with MS when I was 61 and have received treatment for 7 years. I try to focus on the positives with this disease. I went from shots every other day to infusions once a month and if this next medication works, it will be infusions every 6 months. You are not alone out there.

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